Compared to the traditional methods, such as invasive surgeries, radiation and chemotherapy, immunotherapy is more specific and less toxic to patients. Immunotherapy has become a revolution in the area of cancer treatment. Tumor-infiltrating Lymphocytes-based Antibody Discovery ServiceĪll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease. Screening for COVID-19 T-cell Peptides and Immune Monitoring with MHC Tetramers.Angiotensin-converting Enzyme 2 (ACE2)-CHO Cell Line Model for COVID-19. Cancer Vaccine Analytical Characterization.Induction of Antitumor Cytotoxic Lymphocytes Using Engineered Human Primary Blood Dendritic Cells.CellRapeutics™ Chimeric Engulfment Receptor (CER) Technology.CellRapeutics™ TCR/CAR/Antigen-Engineered Regulatory T Cells (Tregs).Antibody-Coupled T Cell Receptor (ACTR) Platform.NR4A Knock Out CAR-T Cell Development with CRISPR Technology.TRAC-CAR-T Cell Development with CRISPR/Cas9 Technology.Nanoparticle Tiny Tech for Programming T Cells.High-throughput Screening for T Cell Activity Modulator Discovery.Modular CAR-T Cell Generation with AAV-Cpf1.Organoid-induced Differentiation of Conventional T Cells from hPSCs.CellRapeutics™ Antibody-TCR (AbTCR) Technology.CellRapeutics™ Anti-HIV CAR Cell Therapy Development.TCR-Like CAR Construction and Evaluation Service.TCR-Like Antibody Affinity Characterization.MHC/Peptide Complex Production for TCR-Like Antibody Discovery.One-stop Cytokine Release Syndrome (CRS) Management Solutions.iPSC-derived CAR-NK Therapy Development.TCR Biomarker Identification & Selection.Replication-Competent Virus Testing Service.In this review we will retrace the history of antibodies from the times of serum therapy to modern mAbs and lay out how the current run for effective treatments against COVID-19 will lead to a quantum leap in scientific, technological and health care system innovation around mAb treatments for infectious diseases.ĬOVID-19 Innovation Monoclonal antibody mAb serum therapy.Ĭopyright © 2020 The Authors. This trend is further accelerated by ongoing or imminent health crises like COVID-19 and antimicrobial resistance (AMR), where antibodies could be the last resort. MAbs against devastating diseases like Ebola, HIV and other complex pathogens are now within reach. Vast advances in mAb isolation, engineering and production have entirely shifted the cost-efficacy balance. The development of urgently needed and highly effective mAbs as preventive and therapeutic treatments against a variety of pathogens is gaining traction. Only very few mAbs against RSV, anthrax, Clostridium difficile or rabies have reached the market. For years the high production cost and limited efficacy have blocked broader application of mAbs in the infectious disease space, which instead has been dominated for almost a century by effective and cheap antibiotics and vaccines. Instead, development of effective mAbs against infectious diseases has been lagging behind. This success is mainly driven by treatments in the oncology and autoimmune space. In recent years the global market for monoclonal antibodies (mAbs) became a multi-billion-dollar business.
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